Watertown, MA

Openings, closings & business in Watertown

New restaurants, storefront changes, and local business news in Watertown, MA. Updated daily from the Watertown morning brief.

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Avilar Therapeutics Names Leslie Meltzer CEO

Watertown-based Avilar Therapeutics announced Oct. 7 that Leslie Meltzer is its new chief executive officer. The company is advancing its lead ATAC protein-degradation program toward clinical trials.

Oct 8 · Patch →

MassVentures START Winners and Judges Party at Labshares Tonight

MassVentures' 2026 START Winners and Judges Party runs tonight, 5:30 to 7:30 p.m., at Labshares, 66 Galen St.

Oct 7 · MassVentures →

Free Fall Open House at Fly Together Fitness Today

Fly Together Fitness hosts a free Fall Open House today, Saturday, Oct. 3, inviting the community to try aerial and pole fitness.

Oct 3 · Fly Together Fitness →

Badam Uyghur Cuisine Plans November Opening at 58 Mt. Auburn St.

Boston.com reported Oct. 2 that Badam Uyghur Cuisine plans to open in November. The menu includes hand-pulled noodles, lamb kebabs and rice pilaf.

Oct 3 · Boston.com →

Biotech startup Ai3Bio raises $49 million

Patch reported that Ai3Bio, a biotech startup with a Watertown presence, raised $49 million to develop autoimmune-disease treatments, including for rheumatoid arthritis and lupus.

Oct 2 · Patch →

Biotech Community Oktoberfest Today at 155 Arlington Street

BVS hosts its fourth annual outdoor biotech Oktoberfest today from 2:00 to 5:30 p.m. at 155 Arlington Street, with vendor exhibits, food and drinks, networking and lab tours.

Oct 1 · BVS →

Pascal Technology Opens Watertown Headquarters

Pascal Technology, which is working on a way to cool things without the environmentally harmful gases used in refrigeration, has opened its new headquarters in Watertown.

Oct 1 · Watertown News →

Student Startup Trek Tours Tutor Intelligence's Watertown HQ

The Massachusetts AI Coalition leads a tour of Tutor Intelligence's robotics headquarters at 480 Pleasant St. Tuesday, Sept. 29, from 4 to 6 p.m.; the event is open to current college students who register with a school email.

Sep 29 · Massachusetts AI Coalition →

Biotech Community Oktoberfest — Thursday in Watertown

Biotech Vendor Services hosts the Biotech Community Oktoberfest Thursday, Oct. 1, 2:00–5:30 p.m., at Cambridge Scientific Labs, 155 Arlington St.

Sep 27 · Biotech Vendor Services Inc. →

Walk and Talk Explores Coolidge Square

A Walk N Talk through Coolidge Square, in partnership with the Watertown Business Coalition, runs Thursday, Sept. 24, from 1 to 2 p.m., exploring local businesses and the neighborhood.

Sep 24 · Live Well Watertown →

Brokerages Face Off in Watertown Karaoke Fundraiser

YPN Battle of the Brokerages runs Thursday, Sept. 24, from 6:30 to 9:30 p.m. at Watertown Sons of Italy, with real estate groups competing in karaoke to benefit HomeStart.

Sep 24 · Greater Boston Real Estate Board →

WEST Hosts Pacific Crest Trail Leadership Talk at Seismic Therapeutic

WEST hosts a talk at Seismic Therapeutic, 250 Arsenal St., Thursday, Sept. 24, from 5:30 to 7:45 p.m., where speaker Kristen Hege discusses leadership lessons from her Pacific Crest Trail hike and her career in cancer immunotherapy research.

Sep 24 · WEST (Women in the Enterprise of Science and Technology) →

GenScript Hosts Watertown Biotech Mixer

GenScript hosts a Watertown Biotech Mixer Wednesday, Sept. 23, from 4 to 7 p.m. at Mighty Squirrel Taproom & Kitchen in Arsenal Yards for scientists, researchers, and biotech professionals.

Sep 23 · GenScript →

Coffee-and-Coworking Session Set for Mighty Squirrel

Stargazer Creative hosts a free coffee-and-coworking gathering Wednesday, Sept. 23, from 9 a.m. to 2 p.m. at Mighty Squirrel Brewing Co. in Arsenal Yards for networking and remote work.

Sep 23 · Stargazer Creative →

Buff's Pub Plans Second Location on Arsenal Street

NBC Boston reported Sept. 21 that Newton's Buff's Pub plans a second location at 46 Arsenal Street in Watertown, in the former Belle's space, pending transfer of a beer-and-wine license.

Sep 23 · NBC Boston →

Belle's Burgers & Ice Cream to close after 22 years

Belle's Burgers & Ice Cream at 46 Arsenal St. will serve its final burgers and ice cream on Friday, Sept. 25; Buff's Pub is reportedly expected to take over the space.

Sep 22 · Boston.com →

Buttermilk & Bourbon hosts one-night Down & Dirty dinner

Buttermilk & Bourbon at Arsenal Yards hosts a one-night, three-course oyster dinner Tuesday, Sept. 22, at 6 p.m., featuring bourbon-and-bacon casino, jambalaya with fried oysters, and dessert with bourbon pairings.

Sep 22 · Boston Chefs →

40 Watertown Open Houses Scheduled Today

Homes, condos, townhouses and multifamily properties across Watertown are open for viewing today, Sunday, September 20.

Sep 20 · Watertown News →

Home Taste Space May Become Uyghur Restaurant

Home Taste at 58 Mt. Auburn St. has closed, and signage suggests Badam Uyghur Cuisine may take over the space; the long-term plan remains unclear.

Sep 20 · Boston Restaurant Talk →

Google Signs 35,000-Square-Foot Office Lease in Watertown

Google finalized a 35,000-square-foot lease at Alexandria Real Estate Equities' Arsenal on the Charles campus at 200 Talcott Avenue on September 17, 2026.

Sep 18 · Banker & Tradesman →

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